Chest x-rays of monkeys with pneumonia. The journal of experimental medicine. 1896.
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New 3D imaging system could address limitations of MRI, CT and ultrasound
In a proof-of-concept study funded by the National Institutes of Health, researchers from the Keck School of Medicine of USC and the California Institute of Technology (Caltech) have shown that an innovative, noninvasive technique can be used to quickly collect 3D images of the human body, from head to foot. The technology combines ultrasound and photoacoustic imaging, which detects sound waves…
New 3D imaging system could address limitations of MRI, CT and ultrasound
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New Paper Published - Understanding Laminin N Terminus Alpha 31’s Role in Corneal Healing
I’m very pleased to tell you about our latest paper published this week in PLOS One.
Its been a long time coming, the manuscript co-first authored by two of the lab’s former PhD students Dr Lee Troughton, now at Loyola University and Dr Valentina Iorio now managing the teaching labs at University of Liverpool. Indeed, most of the team through the years contributed to this work with former PhD…
New Paper Published - Understanding Laminin N Terminus Alpha 31’s Role in Corneal Healing
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Just got some imaging done and yall I thought my teeth were bad before but sweet lords why do they look like they’re trying to ESCAPE
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Sunrise Lens in the Sky
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A pair of clockwise-rotated images in a composition of a sunrise installed in a cloudy sunny sky
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Back pain can come from injuries, daily habits, or deeper spinal issues, and knowing when it’s serious matters. This video explains common causes of upper and lower back pain, warning signs you shouldn’t ignore, and how fast emergency care with imaging can help you recover safely. Visit The Emergency Center today.
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Perimeter Medical Imaging AI, Inc. (PINK:CA) Shareholder/Analyst Call Prepared Remarks Transcript
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Perimeter Medical Imaging AI, Inc. (PINK:CA) Shareholder/Analyst Call December 29, 2025 1:00 PM EST
Company Participants
Suzanne FosterMatthew Imrie
Presentation
Operator
Hello, and welcome to the Annual General Meeting of the Shareholders of Perimeter Medical Imaging AI Inc. Please note that today’s meeting is being recorded. If you participate in today’s meeting and disclose personal…
Perimeter Medical Imaging AI, Inc. (PINK:CA) Shareholder/Analyst Call Prepared Remarks Transcript
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Developments in Magnetic Particle Imaging
Abstract
Magnetic Particle Imaging (MPI) is a new medical imaging technique that has developed rapidly over the last 20 years.
It detects special magnetic nanoparticles (SPIONs) using changing magnetic fields.
By detecting SPIONs, MPI can
- Visualize blood flow
- Detect diseases
- Guide medical procedures.
MPI is very sensitive, can create 3D images in real time, and doesn’t use harmful radiation.
Thanks to its high sensitivity, MPI can be used for many purposes, including heart and blood vessel imaging, stroke detection, and tracking cells in the body.
MPI is getting closer to clinical use.
[[MORE]]Link: https://www.sciencedirect.com/science/article/pii/S0006291X25012252?via%3Dihub
- Introduction (Simplified)
MPI works by detecting SPIONs using static and changing magnetic fields. This provides high sensitivity, background-free imaging, and no harmful radiation.
MPI can also distinguish between different types of particles or conditions. Human-scale scanners for imaging the brain and legs have recently been developed, and a clinically approved tracer (made of SPIONs; marks so scanners know where to look / what to measure) is now available in some regions.
- Instrumentation Developments
MPI uses three key magnetic fields to detect and map SPIONs:
- Drive Field (DF): fast; low-strength; it defines where the scanner pays attention
- Selection Field (SF): static magnetic gradient; created by coils; makes the SPIONs wiggle which makes them more detectable
- Focus Field (FF): slower; high-strength; moves or expands imaging region (field of view; FOV)
Two main encoding designs are used: field-free point (FFP) and field-free line (FFL) systems.
- Field-Free Point (FFP) Systems: Scans point-by-point
- Field-Free Line (FFL) Systems: Scans line-by-line
Hybrid Imaging Approaches
MPI doesn’t show anatomical detail.
To overcome this, it’s being combined with MRI, CT, and ultrasound technology.
For context:
- Magnetic Resonance Imaging (MRI): Details soft tissue using strong magnets and radio waves
- Computed Tomography (CT): Details bone and structure using X-rays
- Ultrasounds: Detail real-time moving (fetus movements, heartbeats, blood flow) using high-frequency sound waves
How They Link With MPI
- MRI and CT systems combining with MPI can merge functional and structural information.
- Fiducial markers (markers that show up clearly in both systems) help line up images so everything matches.
- Dual-use tracers (nanoparticles that can be seen by multiple imaging methods) also help align images.
- MPI and ultrasound combinations are being studied for targeted thermal therapies (treatments where a specific area is heated up; ultrasounds would help focus sound waves and destroy tumors).
Magnetic Particle Spectroscopy (MPS)
- Related to MPI
- Works without a gradient field
- Some are simpler and more flexible
- Some are limited by power and size.
- Algorithmic Developments
Two main approaches in MPI progress are:
1. System matrix-based reconstruction - describes how nanoparticles respond to magnetic fields.
- Measured, providing accurate calibration of a specific scanner setup
- Modeled, allowing more general use across different systems
2. X-space reconstruction - converts measured MPI signal into image space using FFP or FFL. Signal blurring can occur due to particle relaxation effects.
Field of View (FOV) and Stitching Techniques
- FOV Patching or partial-FOV (pFOV) Reconstruction - Scanners move the FOV and then combine multiple FOVs into one image
- SM-based reconstruction requires multiple system matrices (for multi-contrast).
- X-space reconstruction has differences extracted from the signal characteristics (for multi-contrast).
- MPI’s magnetic fields can be used to control and move magnetic objects. Specialized algorithms now enable precise movement using the selection field.
- Nanoparticular Tracer System Developments
The unique nonlinear magnetic behavior of SPIONs is what makes MPI possible.
The structure and coating of SPIONs determine
- The signal quality in MPI
- How the particles circulate
- How the particles clear in the body
SPIONs are removed by the reticuloendothelial system, leading to accumulation in the liver and spleen. However, their blood half-life is short.
- To address this limitation, red blood cell-loaded SPIONs have been developed.
- RBC-loaded SPIONs circulate much longer.
- RBC-loaded SPIONs can monitor blood flow or brain perfusion.
SPIONs have also been explored for cell labeling, enabling the tracking of specific cells (tumor cells and mesenchymal stem cells have been tested).
SPIONs are often internalized by other cells.
- Cells have a process called endocytosis, where they swallow particles.
- SPIONs are small and compatible, and recognized as edible.
- When SPIONs are internalized by cells, they can’t interact with anything outside.
- For targeted imaging, coated SPIONs are used. Coated SPIONs can bind to glioblastoma (brain tumor) cells, supporting both diagnostic imaging and targeted hyperthermia therapy.
Particle Design and Optimization
- An early clinical tracer named Resovist had a much wider size distribution, with only about 3% of particles in the optimal range.
- Resotran was reintroduced as a clinically approved tracer.
- It performs well, but specialized preclinical tracers still provide better MPI signal quality.
Next-Generation Tracer Concepts
- Superferromagnetic iron oxide nanoparticle chains (SFMIOs): provide 10x higher spatial resolution and signal-to-noise ratio.
- Genetically engineered magnetosomes: biologically produced nanoparticles with improved magnetic properties.
- SMART rhesins: microspheres filled with SPIONs for high-viscosity environments.
- Application Developments
MPI is a new medical imaging technique with strong potential. It can capture images very quickly, making it useful for real-time imaging.
The first MPI experiment on a live animal showed a beating mouse heart. Unlike MRI, MPI doesn’t need patients to hold their breath or use radiation. It’s been tested for procedures like stent placement, angioplasty, and aneurysm treatments.
MPI signals directly reflect how many magnetic particles are there, allowing accurate measurement of blood vessels and blood flow. It has been used to study
- Kidney function
- Stroke
- Internal bleeding
- Changes in blood flow
- Certain cells’ changes over time
Researchers are also exploring MPI for cancer detection, locating lymph nodes in breast cancer or help surgeons find tumor edges.
- Outlook and Clinical Perspective
With the arrival of human-scale scanners and clinically approved tracers, the first human MPI studies are within reach.
For MPI to become part of clinical practice, it must demonstrate clear clinical benefits and answer specific medical questions.
Regulatory approval and clinical validation must progress.
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Euroradiology.com is ideal for medical education, imaging services, or professional healthcare platforms.
View its GoDaddy page here: https://www.godaddy.com/en-uk/domainsearch/find?domainToCheck=euroradiology.com
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Cancer Cells Light Up With a Breakthrough Imaging System - Science News
A new ultra-sensitive imaging system can make cancer cells light up, paving the way for faster and earlier detection. Researchers have created a compact Raman imaging system that can reliably tell tumor tissue apart from normal tissue. The goal is to support earlier cancer detection and make molecular imaging easier to use beyond specialized research […]
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New High-Resolution Imaging Reveals How the Flu Virus Invades Cells - Science News
Scientists have captured an unprecedented, real-time view of influenza viruses as they move across and slip inside human cells. The footage reveals that cells are far from passive targets and instead push and pull against the virus in a surprisingly active struggle. Viewing Influenza Infection With New Precision Fever, sore muscles, and a runny nose […]
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Lumexa Imaging: Not Passing My Inspection
Lumexa Imaging: Not Passing My Inspection
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High-Power Vortex Lasers Could Transform Manufacturing and Imaging - Science News
A major European research effort is beginning as Tampere University leads a €4.4 million Doctoral Network focused on high-power optical vortices, a form of twisting light with remarkable potential. The HiPOVor initiative will train 15 doctoral researchers to develop, amplify, and apply these structured light beams in advanced photonics. U-Funded Network Launches Major Push Into […]
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ICEYE, a global leader in Synthetic Aperture Radar (SAR) satellite technology, has successfully launched five new satellites into orbit, significantly enhancing its space imaging capabilities. [Full story]
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In celebration of Nuclear Medicine and Molecular Imaging Week, we will present a series of nuclear medicine cases that highlight the power of nuclear medicine to image physiology and to image at the molecular level.
Today’s case is a ventilation perfusion scan of a 30 year-old man with shortness of breath and inability to run since childhood. Perfusion images show no defect in the lungs. However, imaging the brain and kidneys revealed shunting of counts to these organs, consistent with right to left shunt. Quantitative analysis revealed 22% of counts were in the brain and kidneys. Ventialtion images were normal (not shown). Case courtesy of Kevin Banks, Radiopaedia.org, rID: 176343
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Weaving Diagnostic Imaging into Physical Therapists’ Scope of Practice with Dr. Lance Mabry
In this episode, I’m joined by Dr. Lance Mabry as we discuss the evolving role of Diagnostic Imaging in the physical therapy profession. We talk about how physical therapists are using Imaging in their practice and talk through the three levels of scope that outline what P.T.s can and can’t do; we then discuss Dr. Mabry’s perspective as a retired U.S. Air Force physical therapist and an assistant professor at High Point University, teaching Diagnostic Imaging and Primary Care P.T. The episode will focus on why expanding jurisdictional scope, to include imaging referral, will benefit the profession going forward and not only create better patient outcomes, but more efficient healthcare as well. We will also discuss how occupational physical therapists can be advocates for change through the APTA, and policy initiatives to come. If you’re interested in the future of the profession, primary care PT practice, or the role Imaging plays in managing patient’s needs, you won’t want to miss this episode. See the extended interview linked below or linked in the bio!