#antigens

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dr-afsaeed
dr-afsaeed

Biodegradable targeted polymeric mRNA nanoparticles enable in vivo CD19 CAR T cell generation and lead to B cell depletion - Research

While chimeric antigen receptor (CAR) T cell therapies have demonstrated therapeutic efficacy against B cell malignancies, widespread implementation of these therapies is hindered by a cumbersome, ex vivo manufacturing process. Delivery of CAR-encoding messenger RNA (mRNA) to endogenous T cells can generate these therapeutic cells in vivo and streamline this manufacturing workflow. To accomplish…

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dr-afsaeed
dr-afsaeed

Chemoradiotherapy facilitates siglec-10+/siglec-9+ macrophage-mediated impairment of CD24+/MUC16+ tumor cell elimination and enhances PD-L2 dependent immunosuppression in cervical cancer - Research

The post-treatment recurrence after chemoradiotherapy remains a major clinical challenge in cervical cancer, and the underlying mechanisms remain incompletely understood. In this study, single-cell RNA sequencing analysis of human cervical cancer tissues before and after concurrent chemoradiotherapy (CCRT) revealed that cervical cancer tumor cells exhibited enhanced stemness along with…

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pixegias
pixegias

Advancing Influenza Vaccine Development: Sino Biological Launches Antigens for the 2026-2027 Northern Hemisphere Influenza Vaccine Strains

The World Health Organization (WHO) has announced its recommendations for the 2026–2027 Northern Hemisphere influenza vaccine composition. The update highlights two key developments: the continued spread of A (H3N2) subclade K and the growing circulation of new B/Victoria lineage strains. In rapid response, Sino Biological, Inc. (Shenzhen Stock Exchange: 301047.SZ), a global leader in recombinant…

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pixegias
pixegias

Postdoc Portrait: Samruddhi Jewlikar Designs Recombinant Antigens and Antibodies for Flavivirus Therapeutics

This postdoc’s work leverages protein engineering, construct design, and biochemical characterization to develop impactful tools for biomedical research.
Image credit:NC Biotech Center, ©iStock.com, koto_feja

Samruddhi Jewlikar is a postdoctoral researcher in Prem Lakshmanane’s group at the University of North Carolina at Chapel Hill. Her research focuses on structure-based design and…

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dr-afsaeed
dr-afsaeed

Preclinical Assessment of HLA-A*02:01-Restricted PSMA and STEAP1 Epitopes for Peptide-Based Immunotherapy in Prostate Cancer - Research

Background:

Peptide-based immunotherapy targeting tumor-associated antigens presents a promising approach for prostate cancer intervention. In this study, we employed a preclinical approach to evaluate immunogenic epitope candidates derived from STEAP1 and PSMA, two well-characterized prostate cancer-associated antigens.

Methods:

High-affinity cytotoxic T lymphocyte (CTL) epitopes restricted…

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southdakotagirl1966
southdakotagirl1966

a short poem…

audio version:

Between stimulus and response, there is a space. In that space is our power to choose our response. In our response lies our growth and our freedom.―Viktor E. Frankl (Austrian neurologist, psychiatrist, philosopher, and Holocaust survivor)


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biology-geology-beaches-india
biology-geology-beaches-india

The Scientific Research Notes Of S. Sunkavally (years: 2002-2011).

2769-2771.

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hometoursandotherstuff
hometoursandotherstuff
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raffaellopalandri
raffaellopalandri

Ode to Crisp Air and Shorter Days: Why I Love Late Autumn and Winter

Daily writing promptWhat is your favorite season of year? Why?View all responses

While I wouldn’t necessarily describe myself as someone who has preferences, thanks to my Buddhist non-attachment, there’s one area where I have a strong and clear affection: the seasons of the year.

Photo by Riccardo on Pexels.com

But here’s the twist – my favourite time isn’t the explosion of life in spring, nor…


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atlxolotl
atlxolotl
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customdesignnnn
customdesignnnn

More Antibodies With Longer Intervals Between COVID Vaccine Doses

More Antibodies With Longer Intervals Between COVID Vaccine Doses

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center.
LISBON, Portugal — An overall ninefold increase in COVID-19 antibody levels can be seen with a longer interval between first and second doses of the Pfizer/BioNTech (BNT162b2) vaccine in people without prior infection, according to data from the UK government’s SIREN (SARS-CoV-2 Immunity and…

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maxcastroperu
maxcastroperu

Scientists Convert Donor Lungs to Universal Blood Type in a Medical First

Scientists Convert Donor Lungs to Universal Blood Type in a Medical First

Patients can wait a long time for potentially life-saving lung transplants, since the need to find close matches complicates the process. One of the characteristics that need to be matched is patient and donor blood type.

Now new research shows that the blood type of some donated lungs could be altered before transplant, which means there is a bigger pool of universal donor lungs and less time…


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reportwire
reportwire

It’s not Telepathy; It’s Telepathology

It’s not Telepathy; It’s Telepathology

CDC pathologist Pleasure Gary views weakened tissue at a multi-headed microscope in a small place. Before the COVID-19 pandemic, the home was generally crammed Joy’s colleagues.

What’s straightforward to confuse with head reading through and allows individuals to see tissue harm from a distance? Telepathology.
That’s when pathologists—scientists who analyze disorder hurt and triggers of…

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naturalwellnessjourney
naturalwellnessjourney

I’m glad I kept my books from college.

If anyone wants to learn more about the immune system and how it truly works I highly reccomend this textbook.

Pathophysiology is so amazing to study! The body is absolutely miraculous.

Innate and adaptive immune system…

T-cell, B-cell & antibodies…. YEARS OF NATURAL PROTECTION…

Absolutely fascinating!!!

#pathophysiology
#disease
#immunesystem
#antigens
#antibodies
#themiraculoushumanbody
https://www.instagram.com/p/CUNlb3_AHSJ/?utm_medium=tumblr

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microbiology-immunology
microbiology-immunology

Evolution of Immune System against Diverse Antigens (Grey Literature)

The immune system is designed to protect us from a diverse range of threats to our body. This dissertation titled ‘Evolution of Immune System against Diverse Antigens’ drafted by Jiming Sheng from the University of California explains about how our body’s defense mechanism behaves when it encounters known, unknown as well as mutant pathogens. There is also a discussion of how the system reacts to vaccines and how the behavior differs based on different age groups.

References:

Sheng, J. (2021). Evolution of Immune System against Diverse Antigens (Order No. 28543594). [Doctoral Dissertation, University of California]. Available from ProQuest Dissertations & Theses Global. (2554337908). Retrieved from https://www.proquest.com/docview/2554337908

Image Credit: Pixabay

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microscopiaiwm
microscopiaiwm

Antigen presenting cells


Introduction

The population of specialized cells: 

to capture microbial and other antigens,display MHC complexes in association with these peptide fragments of protein antigens on its surface to lymphocytes, andprovide signals that stimulate the proliferation and differentiation of the lymphocytes (co-stimulatory signal) are known as the antigen-presenting cells (APCs). 

APCs are…

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sciencenewsforstudents
sciencenewsforstudents

Explainer: What are Antibodies?

A world of germs is vying to invade your body and make you sick. Luckily, your immune system can assemble a mighty army to protect you. Think of this system as your own personal team of superheroes. They are dedicated to keeping you safe.

And antibodies are among their strongest ammunition. Also called immunoglobulins (Ih-mue-noh-GLOB-you-linz), or Ig’s, these are a family of proteins.

The job of these antibodies is to locate and attack “foreign” proteins — that is, proteins that don’t appear to belong in the body.

These foreign invaders contain substances the body doesn’t recognize. Known as antigens, these can be parts of bacteria, viruses or other microbes. Pollen and other things that cause allergies can have antigens, too. If someone is given blood that doesn’t match their blood type — during surgery, for instance — those blood cells can host antigens. 

 Antigens attach to the outside of certain white blood cells. These cells are known as B cells (short for B lymphocytes). The antigen’s binding triggers the B cells to divide. This causes them to transform into plasma cells. Plasma cells then secrete millions of antibodies. Those antibodies travel through the body’s blood and lymph systems, hunting for the source of those antigens.

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wellbodymind
wellbodymind

The immune system: what is it?

How the immune system works

I am not a scientist! I’m trying to make this understandable for non-scientists like me. If I can get these basics down, so can anyone!

The first thing to know is that it’s not like other systems in the body in that it doesn’t consist of specific organs, like the digestive system, nervous system, cardiovascular system, etc. It’s bigger than that.

The immune…

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drawittoknowitmedical
drawittoknowitmedical
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freehealthteacher
freehealthteacher

Discovery of new source of cancer antigens may expand cancer vaccine capabilities

Discovery of new source of cancer antigens may expand cancer vaccine capabilities

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IMAGE: Errors in DNA replication are very rare and repaired. Transcription error rates are higher but also rare as are mis-splicing during intron excision. Additionally, the FS transcript with a premature…
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Credit: Arizona State University

For more than a decade, scientist Stephen Albert Johnston and his team at Arizona State University’s Biodesign Institute have pooled…

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