Nispomeben
CAS 1443133-41-2
MF C21H27NO4 MW357.4 g/mol
N-[(2S)-1-(4-hydroxyphenyl)-3-[(2S)-2-hydroxypropoxy]propan-2-yl]-3-phenylpropanamide
N-{(2S)-1-(4-hydroxyphenyl)-3-[(2S)-2-hydroxypropoxy]propan-2-yl}-3-phenylpropanamidenon-opioid analgesic, 470338M5XD, E1, NRD 135S E1, NRD E1, NRD.E1, NRD135S, NRD135S.E1, NRD135SE.1
Nispomeben is a small molecule drug. Nispomeben has a monoisotopic…
i don’t even have explanations for this but I REALLY love 1st and 2nd (ESPECIALLY SX2) enneagram types and 1L
NOXPAX at E1 London: Lee Ann Roberts, Parfait and more
👉 https://bysumex.com/noxpax-at-e1-london-lee-ann-roberts-parfait-and-more/
NOXPAX Ignites E1 London with a Monumental Night of Hard Techno on 23 January
On 23 January, NOXPAX delivered one of its most powerful events to date at E1 London, drawing more than 1,700 attendees for a night that cemented its position at the forefront of the hard techno movement. With a lineup led by Lee Ann Roberts and Parfait, and supported by DJ Hyperdrive, Cristian Collodoro, and Hortense de Beauharnais, the event unfolded as a relentless, high-intensity celebration of underground electronic music.
From the moment doors opened, the atmosphere inside E1 was electric. The venue pulsed with anticipation, and by peak time, every corner of the space was alive with movement. The energy never dipped—driven by a carefully curated lineup that balanced raw power, precision, and emotional intensity.
Lee Ann Roberts – A Masterclass in Relentless Power
Dutch powerhouse Lee Ann Roberts delivered a headline performance that embodied the essence of modern hard techno. Known for her uncompromising sound and commanding stage presence, Roberts brought a set that was both fierce and meticulously crafted. Her driving kick drums, industrial textures, and dark melodic layers created a hypnotic intensity that held the crowd in a vice grip.
Roberts’ ability to build tension and release it with explosive drops demonstrated why she is considered one of the most respected figures in the scene. Her transitions were razor-sharp, blending high-BPM energy with moments of atmospheric suspense. The crowd responded in full force—hands in the air, synchronized movement across the dancefloor, and an undeniable connection between artist and audience. Her set wasn’t just loud or fast; it was deliberate, immersive, and emotionally charged.
Parfait – Raw Energy and Underground Spirit
Paris-based DJ and Possession co-founder Parfait brought a distinct and rebellious energy to E1. Her set embodied the raw, unfiltered spirit of the contemporary European underground. Fusing industrial rhythms, acid-laced elements, and relentless percussion, Parfait crafted a sonic journey that was both aggressive and deeply danceable.
What sets Parfait apart is her instinctive connection to the dancefloor. She reads the crowd with precision, shifting between pounding rhythms and euphoric crescendos without losing momentum. Her performance at NOXPAX felt visceral—fast-paced, unapologetic, and emotionally intense. The audience fed off her energy, creating a feedback loop of movement and sound that elevated the entire room.
(more in the link)
#bysumex #London #filmmakers
Batı Şeria’da 365 yasa dışı Yahudi yerleşimine dair endişe artıyor
Belçika, Kanada, Danimarka, Fransa, Almanya, İtalya, İzlanda, İrlanda, Japonya, Malta, Hollanda, Norveç, İspanya ve İngiltere
birlikte yayımladıkları ortak açıklamada İsrail’in Batı Şeria’da 19 yeni yerleşim kurma planını sert biçimde eleştirdi. Açıklamada,
“Batı Şeria’daki yerleşim politikasını yoğunlaştırma adımı gibi tek…
Batı Şeria'da 365 yasa dışı Yahudi yerleşimine dair endişe artıyor
Batı Şeria’da 365 yasa dışı Yahudi yerleşimine dair endişe artıyor
Belçika, Kanada, Danimarka, Fransa, Almanya, İtalya, İzlanda, İrlanda, Japonya, Malta, Hollanda, Norveç, İspanya ve İngiltere
birlikte yayımladıkları ortak açıklamada İsrail’in Batı Şeria’da 19 yeni yerleşim kurma planını sert biçimde eleştirdi. Açıklamada,
“Batı Şeria’daki yerleşim politikasını yoğunlaştırma adımı gibi tek…
Batı Şeria'da 365 yasa dışı Yahudi yerleşimine dair endişe artıyor
Getting so stressed out I start crying because in forever young adults 4 Betsy lavender has a dog, but in the original episode she hates dogs and thinks they’re evil so every book is about a boyfriend being bitten by a dog and dying
I somehow forgot how genuinely funny the first episode of Beyond Evil is?
The first time I was definitely enraptured by the growing, unsettling build up of a small town where someone is always watching, but on my third rewatch I am definitely paying more attention to the way they keep skirting the line between comedy and psychological horror in the first two episodes.
Also now that I have watched more of Shin Ha Kyun’s work, it’s pretty obvious why Kim Soon Jin really wanted him - it’s not just that he is a great actor but he’s famously versatile as hell and he really needs to pull all the stops here. Like the salon scene alone is some genuine comedic acting.
[[MORE]]
Hyung Dong Sik!
Speaking of things that hit way more on a rewatch:
1) LDS’ genuine terror at running towards his partner desperately calling for him
2) LDS’ genuine terror at running towards his best friend’s little brother he has seen grown up desperately calling for him
3) I’m trying to pay more attention to how everyone talks this time around and it seems to me like Oh Ji Hoon has to consciously remind himself to call him Sergent Lee and not Hyung at work? Which is another interesting detail and really hammers home the “small town” feeling.
Know that you are lucky because I don’t hit women.
I also forgot how much I genuinely loved how brilliant this flashback is, it perfectly sets up why basically everyone, including the viewer, would be willing to believe that LDS is actually the murder. It’s playing on very familiar tropes and very effectively and I like that we see here the same thing we’ll see later with Kang Min Jeong - it doesn’t mean anything that the victim wasn’t perfect, that they weren’t a “good” victim. Lee Dong Sik might have been known to the police already if he really was fully committed to singing his guitar, drinking, disappearing from home and picking fights, that doesn’t mean anything that happened to him once he was arrested was justified.
Also I like how it already highlights his flaws, it’s very easy to get swept up in Lee Dong Sik’s character and forget them otherwise.
This line also reminds me of an excellent post about how Lee Dong Sik’s benevolent sexism impacts the women in his life and now I’ll try to find it again.
Aigoo, Lee Dong Sik, that psycho gauge of his… really.
First very clear hint to how LDS’ uses his madness and rage! I find it very interesting here knowing as we know now that he and Nam Sang Bae have been working together for years and deeply love and trust each other. Like on one hand I am sure Lee Dong Sik is genuinely a handful to handle, on the other hand Nam Sang Bae knows well that he’s usually acting up for a reason and goes along with the narrative that yes, Lee Dong Sik is just that crazy (while letting him do whatever he wants).
I truly love this bit because HJW just looks SO crushed. The series plays a lot with the tropes of the classic “Big Hot Shot From The City Comes To A Small Rural Townr” from both LDS’ and HJW’s perspective and it’s obvious that HJW definitely feels like everyone is beneath him (and also suspicious as hell) but he still seems like, surprised when things apparently are beneath him? Oh no, the old country cop’s office is a mess. Who could have seen this coming.
I really like how the camera work here encourages us to look at LDS as if we were HJW when we don’t know yet that Han Joo Woon is here to catch Lee Dong Sik.
Instead it contrasts it with the previous Nam Sang Bae scene of how Lee Dong Sik is different from everyone else in the messy, small station by having a remarkable knowledge of the law (as well as handling well the man who came in for a report). Of course, knowing that Han Joo Woon is here to arrest him, this scene now for Han Joo Woon is 50% about how impressive Lee Dong Sik is and 50% about how Lee Dong Sik probably knows the law so well to get away with murder better.
This is abuse of power.
I love this restaurant scenes because I love all the scenes that show Park Jeong Je, Oh Ji Hwa and Lee Dong Sik hang out as the three childhood friends that are and I love all the scenes where people hang out with their loved ones in a relaxed manner, but it’s also a great set up to all the other themes of the series.
Oh Ji Hoon isn’t wrong, he’s only wrong in this scenario specifically because it was Lee Dong Sik doing it and he would never. Oh Ji Hwa even explicitly tells her brother to blindly trust his partner, but the only reason why that isn’t like, terrible advice is because it’s Lee Dong Sik and he would never break that trust.
It’s also a great scene for the viewers because it shows up that this might be a small substation in the middle of nowhere where nothing very important happens, but there real people working there, not just props for the HJW vs LDS show down. Oh Ji Hoon has doubts and questions and is not simply showing up to collect his paycheck.
Another two great little moments for the trio, who not only know him so well that they know apparently LDS just goes around doing kind things and pretending they were mere accidents but also immediately clock the significance of HKH’s son being here. I don’t think they have any suspicions yet (LDS might but it’s not a serious anything) but they notice the significance of it.
Also Park Jeong Je’s is getting worked up on Han Joo Woon’s “great connections” and him possibly becoming Lee Dong Sik’s partner when Lee Dong Sik doesn’t even like the guy.
Lee Dong Sik, what are you doing right now?
Another moment I really like - Nam Sang Bae immediately puts a stop to Han Joo Woon complaining before he actually finishes complaining and makes Nam Sang Bae actually reprimand him.
Also man, Han Joo Woon is such a pain in the ass here and he even thinks it’s his right - of course Nam Sang Bae handed him over to Lee Dong Sik so he could knock some sense in his head. It’s another scene that also hits differently remembering this is the same situation they had with Lee Sang Yeob.
Once again I love Nam Sang Bae more shrewd moments. I think in the casefile he gets called an “Old Tiger” forced to retire to the countryside and it’s a great description of how much he is hiding while playing Jolly Grumpy Small Town Chief.
I think that their first car scene might actually be the first time that Lee Dong Sik begrudgingly feels himself soften towards Han Joo Woon. He has been nothing but an absolute dick to him so far, but seeing this young lieutenant obsessively wiping everything in the car probably made him reconsider that when Han Joo Woon meant that he didn’t like touching other people’s hands, like he was being a complete dick to him, but also he wasn’t making things up just to sneer at him.
Seven days ago. Around hour 19:20.
Another cool detail here is that this is the first time that Lee Dong Sik throws’ back in Han Joo Woon’s face the importance of evidence. Which is going to suit HJW’s ability to memorise everything splendidly. Also I find it interesting because Lee Dong Sik is, also begrudgingly, actually doing his job of mentoring his younger partner. He super doesn’t want to and HJW’s would fight him tooth and nail on this even if he did, but he’s actually taking the time to teach him things while he’s being ominous.
It’s also very nice of him to not point out that it’s even easier to pay attention to Han Joo Woon’s movements when he’s driving around in a stupidly flashy car.
Also I loved Han Joo Woon genuinely getting upset that Lee Dong Sik hasn’t even received a report through appropriate channels. You think he might be a serial killer but it’s unfathomable that he receives work-related calls on his personal phone?
But it’s interesting when combined to everything that has been happening before, including him witnessing LDS’ deep knowledge of the law. LDS might be a serial killer but until know he was the only cop properly following procedures and Han Joo Woon relied on it.
Also he just hates when things aren’t done properly.
Han Joo Woon’s “City Boy In The Country Side” moments are genuinely funny because he deserves all of them, but also they really highlight the discrepancy between his theoretical and practical experience. The Future of The Nation And Probably Future Chief Of Police Just Like His Father who graduated magna cum laude at the National Police Academy is going on patrol in the countryside with his fancy office shoes. He really put zero thought into his plan and just rushed to Manyang armed with nothing but a dream.
What do you mean by hard work? Working at the forefront of public safety means that you will be covered in soil and have to step in poop. Well, that’s just how it is.
This scene also cracks me up because Nam Sang Bae and Lee Dong Sik are mirroring each other and being judgemental of their newest recruit while sipping their nice cup of teas, but also I do like once again the underlying element of both of them acknowledging that HJW is a pain but still giving him a crash course on, like, everything. Even Nam Sang Bae forcing him into joining a team dinner has this element of “You are coming and learning how people work, end of story. Also next time consider that if someone hadn’t lied, maybe they could have stayed home”.
Nam Sang Bae’s angle is interesting because we know that he was a detective under Han Ki Hwan and from the casefile we know that HKH was forcing him into methods of policing he really didn’t like and always regretted, so there is zero love lost there and he was also probably on guard to see what kind of person Han Joo Woon is.
So far I guess the verdict is: a pain in the ass.
That punk must’ve taught him.
Another great scene when it comes to playing with Lee Dong Sik and Han Joo Woon’s perspectives as we are re-introduced to the same people from the previous intimate, personal dinner in a professional, team meeting dinner instead. One of the most striking things is that, from a serial killer-catching perspective, this is both an interesting clue and also a nightmare.
On one hand, serial killers integrating themselves with the community and the police to have a front row to their own murders and interfering with their own investigation is a classic, and combined with the way Lee Dong Sik is highly knowledgeable of kidnapping and murder laws, it does seem like a sign that Han Joo Woon is right.
On the other hand, Han Joo Woon doesn’t know yet that Lee Dong Sik is a pariah in Manyang, so to him it must look like he’s actually incredibly well connected. His best friend is the Chief Administrator and the son of a powerful local councilwoman! His other best friend is a Lead Detective at the Violent Crime Divison of Munju! The Chief looks to him benevolently! He’s even friends with the owner of the only grocery store! He really can get away with murder and no one will ever give him up!
Also I love the way he turns puzzled when Oh Ji Hwa talks about “That punk” and sees Lee Dong Sik standing there. This is possibly the most interest Han Joo Won has had so far into another human being and he’s basically immediately hit on the head immediately about how people aren’t that simple, here’s a complete overview of Lee Dong Sik at work, with the public, with his colleagues and with his friends and family. Also once again, I truly adore the friendships in this show.
Another moment where I think Lee Dong Sik finds himself softening and understanding Han Joo Woon a bit better, despite everything: I think he still disagrees that people “are that simple”, but now he DOES have a front row to everyone wanting to talk about Han Joo Woon’s father and what a powerful man he is. Oh Ji Hwa was fishing around on whether there is any chance Han Joo Woon wasn’t in Manyang by coincidence, but everyone else certainly wasn’t. Considering that Lee Dong Sik has first hand experience with everyone making assumptions about what kind of person he is, he certainly can relate.
The Viki subtitles give me the “You are the loner type” line from Netflix as “You really aren’t the type to have friends. I like that.” and I think he’s sincere about it. Han Joo Woon is a mess but at least he’s an honest mess.
And the worst undercover guy in the world after refusing the chance of being Lee Dong Sik’s partner, which would allow him to, you know, INVESTIGATE HIM BETTER and then flees from a team dinner WITH ALL THE PEOPLE HE SUSPECTS MIGHT BE COVERING FOR HIM. Han Joo Woon you are so bad at this.
In fact he’s so bad at it that Lee Dong Sik immediately realizes that Han Joo Woon is aware of his past and starts getting suspicious about it. Or maybe he’s just upset that his new partner has already bought the rumours.
At this rate, our little boy might become a real cop.
I really like the class element at play here because despite everything, Kwon Hyeok is echoing the same feelings as Nam Sang Bae on what being a cop is actually like and what a cop is supposed to be. Say what you want but Han Joo Woon was a Lieutenant at Foreign Affairs, and yet Kwon Hyeok sees it “not a real cop” as in “not a real job” - which is also, an interesting opinion to have as a prosecutor.
And also literally no one around Han Joo Woon apparently thinks he’s worth a damn? Which I’m sure it’s doing wonders for him as a person.
It is awesome. A family can’t be broken.
Another building block of Han Joo Woon’s worldview here - of course he thinks everything in life is transactional if his only, uh, Kwon Hyeok in the world admits openly that he was immediately loyal to Han Ki Hwan because of money.
Of course HJW doesn’t understand enough about the world/people to understand why such an act would impress Kwon Hyeok so much, he only sees that a transaction happened and now a relationship was born - but it explains more about him.
Also what a line to say about the Han family. And also about every family in Beyond Evil.
He couldn’t explain how his partner died.
Gods, people must have really hated Han Joo Woon’s guts (and viceversa) at Foreign Affairs. I’m not just talking about how they dismissed what was actually a solid theory, but also how, going by body language, it seems like Han Joo Woon has just found out that Lee Dong Sik is FAMOUS for being “the Lunatic of the RIU”. He must have gone through official sources and cases to get those pictures for his power point and not a single person ever thought to let him know something that apparently everyone else knew.
Also very interesting that as far as I remember, Han Joo Woon never brings up Lee Dong Sik’s previous partner. It’s possible that he just dismissed it because I don’t think it would have fit at all with whatever profile of Lee Dong Sik as a serial killer he was working with, but still.
Han Joo Woon, you know who this woman is, don’t you?
I forgot how absolutely impressive it was that he got all of that by Han Joo Woon’s trembling and taking a step back. Like he could have thought there was a chance that he was connected to this case since he found out about his father, but that was still a pretty impressive deduction to make.
This smile really sets the tone on your first watch and what kind of impression Lee Dong Sik makes, but it’s completely different once you know about Lee Dong Sik’s hysterical laughter. He’s smiling because his past is flashing right in front of his eyes, a new victim has just been found and the son of Han Ki Hwan is accusing him of murder. It never fucking ends.
The Right Stuff (2020) Sierra Hotel
E1
It’s 1959 and Russia is winning the space race. In order to compete, The United States forms NASA and chooses to recruit the nations best test pilots to form what will become the Mercury Astronauts. Among these test pilots are the golden boy John Glenn, the reckless Alan Shepard, and Gordo Cooper, whose broken marriage could cost him a place at the program…
*The scene in which Glynn Lunney says he did not include any Marine pilots on the list because the Navy told him the Marine pilots were their washouts is amusing but inaccurate. In real life, there were no Marines on the initial candidate lists because Dr. Robert Voas, the Navy representative in the selection group, erroneously thought that the Marine pilots’ records were in the same files as the Navy pilots, since they trained together at Patuxent River. John Glenn and another Marine were added to the list near the end of the process.
Fanttik T1 Max Wireless Soldering Iron plus various bundles up to 40% off! #sale #discount #fanttik #soldering #screwdriver #wireless #bundle #rotary #drill #duster #diy #maker
Fanttik T1 Max Wireless Soldering Iron plus various bundles up to 40% off!
what a week it has been for the podcast fan, who is lower than a dog and deserves nothing but to lick the dirt off the ground but instead is being given so many wonderful videos and songs and audio instead of being whipped with a chain over and over again
